science is motivated by the need to provide effective treatments
to the right patients at the right doses for a specific disease
indication). The term is used mostly in the health sciences and refers to
real-time translation of bench science, conducted
in a lab, to bedside clinical practice or dissemination
population-based community interventions.
Source: NIH -- Read more
Academic Breast Cancer
Ruth O'Regan, M.D.
Wisconsin, Madison WI
Dr. Ruth O’Regan is the Division Head of Hematology and Oncology in
the Department of Medicine at the University of Wisconsin School of
Medicine and Public Health.
Dr. O’Regan is an internationally recognized breast-cancer
physician and researcher with particular expertise on breast cancers that
are resistant to current therapies.
A native of Dublin, Ireland, O’Regan previously was a professor of
hematology and medical oncology at Emory University, where she held the
Louisa and Rand Glenn Family Chair in Breast Cancer Research.
Additionally, O’Regan was the medical director at Glenn Family Breast
Center of Emory University, director of the Breast Cancer Translational
Research Program at the Winship Cancer Institute, and chief of hematology
and medical oncology at the Georgia Cancer Center for Excellence at Grady
In her dedication to training the next generation of physicians, O’Regan
served as vice chair for educational affairs in the department of
hematology and medical oncology and as director of the
hematology/oncology fellowship program at Emory University.
With a highly active research program focused on identifying mechanisms
of resistance to breast-cancer therapies and development of new
therapies, O’Regan has been principal investigator for numerous grants
and clinical trials.
Her research group has made significant discoveries about the role of the
PI3 Kinase-mTOR pathway in triple-negative breast cancer, showing that
mTOR inhibition can sensitize breast-cancer cells to upstream
growth-factor inhibitors. These discoveries resulted in a novel clinical
trial for patients with metastatic breast cancer.
About University of
Wisconsin Carbone Cancer Center
UW Health consists of the academic health care entities of the
University of Wisconsin-Madison: UW Medical Foundation, UW Hospital and
Clinics and UW School of Medicine and Public Health. UW Health is also
home to American Family Children's Hospital and UW Carbone Cancer Center.
Our expert doctors are at the forefront of research, developing new
treatments and training the next generation of physicians. This network
provides access to more than 1,200 primary and specialty care physicians
who are leaders in their fields, as well as the opportunity to be treated
at University of Wisconsin Hospital and Clinics, frequently cited in
published rankings of the finest academic medical centers. Learn more